Prolific comedian Patton Oswalt and Notorious P.I.G. Martin Shkreli went (virtually) head-to-head on Twitter in a roast almost as fiery as Rob Lowe's.

It all started when the comedian (Oswalt) joked about the #TrumpCantSwim hashtag on Twitter, because that's what comedians do, and the price gouger of life-saving drugs (Shkreli) decided to chime in.

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A fan (of Oswalt's) answered Shkreli, citing Oswalt's most famous credit, and Shkreli was unsatisfied.

Oswalt then chimed in himself with a great burn that the pharmaceutical CEO will need a prescription to fix.

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