In interviewer school, did they teach you that it's a good idea or bad idea to call your subject a skank? (Start the video at 1:50 to skip to the horrible part.)
I think these two radio hosts are playing Good Interviewer, Bad Interviewer. The woman asks Schumer thoughtful questions and compliments the film, while the dude bro offends her (and me) over and over again.
At the beginning of the interview, Schumer explains that her character in the film is based on herself.
"It's me like 10 years ago, when I was a sophomore in college. I was in a lot of pain and I was spreading myself too thin, I was drinking a lot and, and I uh, and then I just realized how destructive it was."