Garry Shandling—the stand-up comedian and creator and star of the acclaimed and groundbreaking television shows It's Garry Shandling's Show and The Larry Sanders Show—died today at the age of 66, multiple news outlets have reported. Shandling had a massive influence on comedy, particularly television comedy—it's hard to imagine that shows such as 30 Rock, Arrested DevelopmentCurb Your Enthusiasm, and both versions of The Office would have ever existed without HBO's The Larry Sanders Show, which explored the behind-the-scenes machinations at a fictional talk show. Because of this, many comedians, including real talk-show hosts, have been the first to react to the awful news: