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Alison Brie as... Ugh... Muffy the Vampire Slayer.

I would like to point out that at some point in 2007, a young, unknown actress named Alison Brie was terribly sad because Comedy Central passed on this pilot for Not Another High School Show:

You see, she was going to be one of the leads in this weekly spoof-fest from the guys who brought us Not Another Teen Movie. She was Muffy the Vampire Slayer. This was going to be her break out role! This was going to be the show that made her a star. But with one stroke of a pen, the suits at Comedy Central destroyed all of her hopes and dreams. 

Sources: JCIce007 | h/t Gawker