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South Park is a bit of a wild card when it comes to social commentary, and they tend to attack things that are either very current or very obscure. In the most recent episode, Tweek x Craig, they take on an art form many know about, but which is rarely addressed on a huge network TV show. Yaoi, the Japanese slang word for "boys love," is also an illustration style popular amongst female fangirls of anime and other shows. Kind of like how guys, it's been rumored, enjoy depictions of girls doing similar things. Or, as Kyle explains:

Sources: Comedy Central